Phospholipid signaling

Phospholipid signaling

Ten years ago, describing what is new in phospholipid signaling in ten pages of Cell would have been easy; it would have been essentially a summary of the phosphoinositidase C (PIC) story: phosphatidylinositol(4,5)bisphosphate (Ptdlns(4,5)P2) hydrolysis to inositiol(1,4,5)trisphosphate (Ins(1",4,5)P3), with the synergistic action of Ca 2÷ (mobilized by Ins(1,4,5)P3) and diacylglycerol (DAG) on ...

Plant phospholipid signaling: "in a nutshell".

Since the discovery of the phosphoinositide/phospholipase C (PI/PLC) system in animal systems, we know that phospholipids are much more then just structural components of biological membranes. In the beginning, this idea was fairly straightforward. Receptor stimulation activates PLC, which hydrolyses phosphatidylinositol4,5-bisphosphate [PtdIns(4,5)P2] into two second messengers: inositol 1,4,5...

Roles of phospholipid signaling in chemoattractant-induced responses.

Chemoattractants, including chemokines, play a central role in regulation of inflammatory reactions by attracting and activating leukocytes. These molecules have been found to regulate metabolism of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) via phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K). Recent studies of mouse lines that lack PLC-(beta)2, PLC-(beta)3, or PI3K(gamm...

Signaling a Role for Phospholipid-Derived Compounds in Plants

Phospholipid Signaling Responses in Salt-Stressed Rice Leaves

Salinity is one of the major environmental factors limiting growth and productivity of rice plants. In this study, the effect of salt stress on phospholipid signaling responses in rice leaves was investigated. Leaf cuts were radiolabeled with 32P-orthophosphate and the lipids extracted and analyzed by thin-layer chromatography, autoradiography and phosphoimaging. Phospholipids were identified b...